Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis TherapyA Randomized Clinical Trial
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Open Access
- 24 February 2010
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 303 (8), 739-746
- https://doi.org/10.1001/jama.2010.158
Abstract
The rate of severe sepsis hospitalizations has doubled during the last decade with estimates indicating that at least 750 000 persons are affected annually in the United States.1-3 Approximately, 500 000 patients with severe sepsis in the United States annually are initially treated in emergency departments.4 The Surviving Sepsis Campaign international consensus guidelines recommend protocol-driven treatment that uses quantitative resuscitation for emergency department patients with severe sepsis and septic shock.5Keywords
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