Glycosylation of macrolide antibiotics in extracts of Streptomyces lividans
- 1 February 1992
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 36 (2), 348-352
- https://doi.org/10.1128/aac.36.2.348
Abstract
Inducible resistance to macrolide antibiotics in Streptomyces lividans involves MGT, a macrolide glycosyl transferase that utilizes UDP-glucose as cofactor. Substrates for MGT include macrolides with 12-, 14-, 15-, or 16-atom cyclic polyketide lactones (as in methymycin, erythromycin, azithromycin, or tylosin, respectively), although spiramycin and carbomycin are not apparently modified. The enzyme is specific for the 2'-OH group of saccharidic moieties attached to C-5 of the 16-atom lactone ring (corresponding to C-5 or C-3 in 14- or 12-atom lactones, respectively).Keywords
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