Effect ofL. usitatissimum(Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation
Open Access
- 17 February 2013
- journal article
- research article
- Published by Hindawi Limited in ISRN Inflammation
- Vol. 2013, 1-4
- https://doi.org/10.1155/2013/735158
Abstract
The present investigation summarizes the effect ofLinum usitatissimumfixed oil against different phases of acute inflammatory reaction, namely, protein exudation, peritoneal capillary permeability, and leukocyte migration. The fixed oil exhibited dose-dependent inhibition of protein exudation vascular permeability, comparable to standard aspirin. The oil also inhibited the leukocyte migration in pleural exudates in a dose-dependent manner. Production of less vasodilatory (PGE3) and chemotactic (LTB5) eicosanoids through EPA (derived from linolenic acid) metabolism could account for the above observations.Keywords
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