Zur Wirkung von Trypaflavin auf den Mäuse-Ascites-Tumor

Abstract

Trypaflavine (the chloromethylate of 3,6-diaminoacridine) has a colchicine-like action and inhibits the division of animal cells. In prophylactic doses, trypaflavine inhibited tumor malignancy as evidenced by increased life span at levels of 0.125 mg./day for 5 days. Trypaflavine was 1/10 as active as colchicine in this respect. Rivanol (the lactate of 7-ethoxy-3,9-diamino-acridine) had no such activity. Trypaflavine had both bactericidal and mitosis-inhibiting power. In 2 human subjects of myelogenous leukemia treated with trypaflavine the white cell counts were considerably lowered. Trypaflavine seemed to relieve mouse ascites tumor. A secondary resistance was induced by the drug. A discussion of the action of mitosis inhibitors in cell division is also presented.