EFFECT OF SYMPATHECTOMY WITHOUT AND WITH ADRENAL INACTIVATION ON THE CONCENTRATION OF EPINEPHRINE AND RELATED COMPOUNDS IN VARIOUS TISSUES

Abstract

Total sympathectomy, combined with adrenal inactivation (complete adrenalectomy or removal of one adrenal gland and demedullization of the other), was followed by a marked diminution of the colorimetrically detd. epinephrine-like substances present in the heart muscle, liver and spleen of cats. In the heart muscle, mere thoracic sympathectomy produced changes of a magnitude equal to that resulting from total sympathectomy and adrenalin activation. Brady-cardia developed following the above-named operations. Plain adrenalectomy without sympathectomy produced less striking changes.