Metabolic Dehydrogenation ofcis- andtrans-Acenaphthene-I,2-diol
- 1 January 1972
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 2 (6), 529-538
- https://doi.org/10.3109/00498257209111081
Abstract
1. The dehydrogenation of cis- and trans-acenaphthene-1,2-diol to ace-naphthenequinone by rat liver microsomal preparations has been established by means of chromatography and isolation. 2. The formation of acenaphthenequinone or a carbonyl precursor of it during incubation of the diols with rat liver microsomes has been followed by a spectrophotometric method and has been shown to be assisted by NAD+ to a greater extent than by NADP+. 3. 1,8-Naphthalic aldehyde was not found as a result of microsomal action on the acenaphthenediols, but under certain conditions 1,8-naphthalic acid was detected in incubation mixtures. 4. Trace amounts of acenaphthenequinone and large amounts of 1,8-naphthalic acid were found in the urine of rats injected with cis- or trans-acenaphthene-1,2-diol or acenaphthenequinone.Keywords
This publication has 8 references indexed in Scilit:
- Microsomal dehydrogenation of cis- and trans-acenaphthene-1,2-diol to acenaphthenequinoneBiochemical Journal, 1969
- Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diolBiochemical Journal, 1968
- The metabolism of naphthalene and its toxic effect on the eyeBiochemical Journal, 1967
- The metabolism of cis- and trans-indane-1,2-diolBiochemical Journal, 1966
- Biochemical studies of toxic agents. Metabolic ring-fission of cis- and trans-acenaphthene-1,2-diolBiochemical Journal, 1966
- Metabolism of polycyclic compounds. 22. The metabolism of (±)-trans-9,10-dihydro-9,10-dihydroxyphenanthrene in ratsBiochemical Journal, 1962
- Biochemical studies of toxic agents. 13. The metabolism of acenaphthyleneBiochemical Journal, 1962
- Enzymic aromatization of 3,5-cyclohexadiene-1,2-diolBiochimica et Biophysica Acta, 1959