Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.
- 1 January 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (2), 479-482
- https://doi.org/10.1073/pnas.82.2.479
Abstract
Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the Ig heavy chain locus. Only one allele is active; the other, silent allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 .times. 10-4 per cell generation. This high rate is termed hypermutation.Keywords
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