A Possible Gastric Secretory Inhibitor in Canine Gastric Juice

Abstract

Alcoholic precipitates from various types of canine gastric juice were tested for their inhibitory action on gastric secretion. Precipitates were from the juice of vagally innervated and vagally denervated gastric pouches stimulated by repeated injns. of methacholine or histamine. In both types of pouches the yield of precipitate per unit volume of juice was about 7 times greater with methacholine than histamine stimulation. With each stimulus it was about twice as great in the juice from vagally innervated as from vagally denervated pouches. The inhibitory action of the precipitates on gastric secretion was tested in dogs with pouches of the Heidenhain type while these were secreting continuously in response to histamine stimulation at about 25% their max. rates. The mean inhibition produced by 100 mg. of precipitate was approx. 75% when the juice was from vagally innervated pouches stimulated by methacholine or histamine. Precipitate from the juice of vagally denervated pouches inhibited secretion by 54% when the juice was stimulated by methacholine and only 25% when stimulated by histamine.