Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue

Abstract

Background: Conjugated linoleic acid (CLA) is a group of naturally occurring fatty acids mainly present in fats from ruminants. CLA has been shown to be a potential anticarcinogen. Objective: In this study, the relation between bovine milk fat intake and the occurrence of CLA in human adipose tissue was investigated. Design: One hundred twenty-three men weighed and recorded the foods they consumed for 1 wk. Afterward, recall interviews were conducted by telephone monthly for 7 consecutive months to inquire about food consumption during the previous 24 h. The entire dietary recording procedure was repeated once. The fatty acid composition of adipose tissue and serum was analyzed. Results: The average amount of one isomer of CLA—9-cis,11-trans-octadecadienoic acid (9c,11t-18:2)—as a percentage of total fatty acids was found to be 0.50% in adipose tissue and 0.25% in serum. The amount of 9c,11t-18:2 in adipose tissue was significantly correlated with milk fat intake (r = 0.42). The percentage of 9c,11t-18:2 in both adipose tissue and in serum was strongly correlated with myristoleic acid (14:1). Conclusion: The amount of 9c,11t-18:2 in human adipose tissue was significantly related to milk fat intake.