Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane‐associated N‐terminal domain
Open Access
- 1 April 2004
- journal article
- Published by Wiley in Protein Science
- Vol. 13 (4), 1031-1042
- https://doi.org/10.1110/ps.03533004
Abstract
Protein Science, the flagship journal of The Protein Society, serves an international forum for publishing original reports on all scientific aspects of protein molecules. The Journal publishes papers by leading scientists from all over the world that report on advances in the understanding of proteins in the broadest sense. Protein Science aims to unify this field by cutting across established disciplinary lines and focusing on “protein-centered” science.Keywords
This publication has 39 references indexed in Scilit:
- Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritisAnnals Of The Rheumatic Diseases, 2003
- A new type of dihydroorotate dehydrogenase, type 1S, from the thermoacidophilic archaeon Sulfolobus solfataricusExtremophiles, 2002
- [20] Processing of X-ray diffraction data collected in oscillation modeMethods in Enzymology, 1997
- SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modelingElectrophoresis, 1997
- The B Form of Dihydroorotate Dehydrogenase from Lactococcus lactis Consists of Two Different Subunits, Encoded by the pyrDb and pyrK Genes, and Contains FMN, FAD, and [FeS] Redox CentersPublished by Elsevier ,1996
- Functional Expression of a Fragment of Human Dihydroorotate Dehydrogenase by Means of the Baculovirus Expression Vector System, and Kinetic Investigation of the Purified Recombinant EnzymeEuropean Journal of Biochemistry, 1996
- The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate DehydrogenaseBiochemistry, 1996
- PROCHECK: a program to check the stereochemical quality of protein structuresJournal of Applied Crystallography, 1993
- Improved methods for building protein models in electron density maps and the location of errors in these modelsActa Crystallographica Section A Foundations of Crystallography, 1991
- A computational procedure for determining energetically favorable binding sites on biologically important macromoleculesJournal of Medicinal Chemistry, 1985