Urinary Histamine Excretion in the Rat Following Skin Homografting and Autografting

Abstract
Skin homografting between female rats of the Sprague-Dawley and Long-Evans rat strains significantly increased urinary histamine excretion. The peak elevation of histamine excretion occurred within a 3 day period of the time of observed rejection. A lesser elevation in histamine excretion was found after autografting. The possible significance of these findings with respect to the effector arc of the immune response to homotransplanted tissue is discussed.