Effect of Histamine on Gastric Peptic Secretion in Man

Abstract

PARENTERAL administration of histamine leads to a marked outpouring of acid and a transient rise in pepsin concentration in the gastric juice. Whether this rise in pepsin concentration is the result of stimulation of pepsin production or whether it represents the "washout" of preformed pepsinogen has been a matter of dispute. Most recorded opinion favors the concept that the parietal cells pour acid out into a canaliculus from which pepsinogen, previously secreted by the chief cells, is passively carried. Previous conclusions about the meaning of blood pepsin levels in relation to gastric secretion have been based in part on this . . .