Acute leukemia expressing the gamma gene product of the putative second T cell receptor.
Open Access
- 1 April 1987
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 79 (4), 1281-1284
- https://doi.org/10.1172/jci112949
Abstract
Early thymus-derived lymphocytes bearing the T gamma gene product in association with the CD3(T3) complex have recently been described. We report a unique case of human acute lymphoblastic leukemia with a CD2+, CD3+, CD4-, CD5+, CD7+, CD8-, WT31- phenotype. These cells were found to have T gamma gene rearrangement and T gamma transcripts in absence of T alpha or T beta rearrangement or transcripts. Immunoprecipitation studies with anti-CD3 antibodies showed a 43-kD protein associated with T3; this 43-kD protein is also precipitated with antiserum raised against synthetic peptides representing the constant region of the putative T gamma protein.Keywords
This publication has 28 references indexed in Scilit:
- A unique T-cell receptor complex expressed on human fetal lymphocytes displaying natural-killer-like activityNature, 1986
- A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytesNature, 1986
- Identification of a putative second T-cell receptorNature, 1986
- Human T-Cell γ Chain Genes: Organization, Diversity, and RearrangementScience, 1986
- Human γ-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7Nature, 1985
- Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18Cell, 1985
- Limited diversity of the rearranged T-cell γ geneNature, 1985
- Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequencesNature, 1984
- The Human T-Cell ReceptorAnnual Review of Immunology, 1984
- Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology, 1975