Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
- 1 August 1997
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 42 (2), 261-264
- https://doi.org/10.1002/ana.410420221
Abstract
The activities of complex I and complex II/III in platelet mitochondria are reduced in patients with early, untreated Parkinson's disease. Coenzyme Q 10 is the electron acceptor for complex I and complex II. We found that the level of coenzyme Q 10 was significantly lower in mitochondria from parkinsonian patients than in mitochondria from age- and sex-matched control subjects and that the levels of coenzyme Q 10 and the activities of complex I and complex II/III were significantly correlated.Keywords
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