THE EFFECT OF DESOXYQORTICOSTERONE ACETATE ON THE BLOOD PRESSURE OF THE DOG1

Abstract

Daily injs. of 20 mg. of desoxycorticosterone acetate (DCA) to normotensive, spontaneously hypertensive and Goldblatt-hypertensive dogs led to elevation of blood pressure in 9 of 12 animals. In 2 of the previously hypertensive dogs, acute pulmonary edema developed and death ensued. The blood pressure changes after cessation of injs. of DCA led a variable course; in some the elevated pressure remained for a considerable period, in others it fell rapidly or slowly to the control pressure levels. The fall in serum K attendant upon adm. of DCA was not related to the blood pressure elevation.