Nucleotide Conversions id various Tissues of Pregnant and Tumor-bearing Mice.

Abstract

In mice, a progressive lowering of blood nucleotide during pregnancy occurs simultaneously with an increase in nucleotide level in the embryos, Injn. of adenylic acid into tumor-bearing mice lowers the nucleotide level in the tumor but not in the embryo. Liver and spleen undergo a lowering of tissue adenosine triphosphate (ATP) during pregnancy, and to a lesser extent during tumor growth. Muscle nucleotide is not altered in mice bearing implanted tumors. Injn. of adenylic acid elevates the ATP level in liver and spleen but not in muscle of normal, tumor-bearing, and pregnant animals. Following adenylic acid injn., liver tissue from normal, tumor-bearing, and pregnant mice shows an increase in total purine, whereas the spleen does not.