Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
Top Cited Papers
Open Access
- 15 December 2009
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 102 (2), 351-360
- https://doi.org/10.1038/sj.bjc.6605486
Abstract
Background: Methods: Results: Conclusion:Keywords
This publication has 40 references indexed in Scilit:
- High-level Coexpression of JAG1 and NOTCH1 Is Observed in Human Breast Cancer and Is Associated with Poor Overall SurvivalCancer Research, 2005
- Expression of the Transcription Factors Snail, Slug, and Twist and Their Clinical Significance in Human Breast CancerAnnals of Surgical Oncology, 2005
- Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesisThe Journal of cell biology, 2004
- Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic LeukemiaScience, 2004
- Modulation of Notch Signaling Elicits Signature Tumors and Inhibits Hras1-Induced Oncogenesis in the Mouse Mammary EpitheliumThe American Journal of Pathology, 2004
- Notch Activation Results in Phenotypic and Functional Changes Consistent With Endothelial-to-Mesenchymal TransformationCirculation Research, 2004
- A causal role for E-cadherin in the transition from adenoma to carcinomaNature, 1998
- The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)Oncogene, 1997
- Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis.1996
- Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development.1995