Propoxyphene Hydrochloride Poisoning
- 27 March 1967
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 199 (13), 1006-1009
- https://doi.org/10.1001/jama.1967.03120130092024
Abstract
ACUTE POISONING after ingestion of propoxyphene hydrochloride (Darvon) is unusual. A fatal overdose is rarer still. There appear to be only two known detailed reports of deaths directly attributable to propoxyphene ingestion,1,2 although there is mention in the literature of at least one other fatality.3 This communication describes a patient who died nine days after taking about 2.3 gm of propoxyphene hydrochloride. Report of a Case A 65-year-old white woman underwent pneumonectomy on the right in December 1963 for an endobronchial papillary squamous cell carcinoma. Postoperatively she did well, and at her last clinic visit in February of 1966, she was asymptomatic. Propoxyphene had been prescribed initially for incisional pain and again in April 1965 for headache. In March 1966 she was brought to the emergency room about one hour after she had ingested, according to her husband, approximately thirty-five 65-mg capsules of propoxyphene hydrochloride. Upon arrival sheThis publication has 5 references indexed in Scilit:
- In vitro Studies of the Mechanism of Polyuria Induced by Dextro Propoxyphene (Darvon).Experimental Biology and Medicine, 1965
- PROPOXYPHENE HYDROCHLORIDE POISONING - REPORT OF FIRST FATALITY1964
- DEXTRO PROPOXYPHENE AND VENTILATORY RESPONSE TO CARBON DIOXIDE IN MAN1962
- Convulsions as a Manifestation of Acute Dextro Propoxyphene IntoxicationArchives of Pediatrics & Adolescent Medicine, 1960
- Effect of N-Allylnormorphine Upon Massive Doses of Narcotic DrugsExperimental Biology and Medicine, 1956