Rifampicin and vitamin D metabolism
- 1 June 1980
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 27 (6), 810-814
- https://doi.org/10.1038/clpt.1980.115
Abstract
A 2 wk course of the enzyme inducing antibiotic rifampicin orally (600 mg/day) in 8 male [human] subjects resulted in a consistent fall in plasma 25-hydroxycholecalciferol (25-OHD) levels of around 70%, accompanied by increased oxidation of antipyrine and 6.beta.-hydroxycortisol (indicative of hepatic enzyme induction). Plasma levels of 1,25-dihydroxycholecalciferol, parathyroid hormone and calcitonin were not altered. The fall in 25-OHD may represent the earliest lesion of drug-induced osteomalacia.This publication has 8 references indexed in Scilit:
- NORMAL PLASMA-1,25-(OH)2-VITAMIN-D CONCENTRATIONS IN NUTRITIONAL OSTEOMALACIAThe Lancet, 1979
- Measurement of urinary 6-?-hydroxycortisol excretion as an in vivo parameter in the clinical assessment of the microsomal enzyme-inducing capacity of antipyrine, phenobarbitone and rifampicinEuropean Journal of Clinical Pharmacology, 1979
- Osteomalacia: Current ConceptsAnnals of Internal Medicine, 1978
- Incorporation of oxygen-18 into the 25-position of cholecalciferol by hepatic cholecalciferol 25-hydroxylaseBiochemical Journal, 1978
- A direct radioimmunoassay for 6β-hydroxycortisol in human urineThe Journal of Steroid Biochemistry and Molecular Biology, 1978
- Basic and Clinical Concepts Related to Vitamin D Metabolism and ActionNew England Journal of Medicine, 1977
- Plasma 1,25-Dihydroxyvitamin D Levels in Patients Receiving Anticonvulsant DrugsJournal of Clinical Endocrinology & Metabolism, 1977
- A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasmaArchives of Biochemistry and Biophysics, 1976