Abstract
SUMMARY: Oestradiol dipropionate enhances the effect of both endogenous and exogenous adrenocorticotrophic hormone (ACTH) on the weight of the adrenal glands of the male rat. Methyl testosterone has the opposite effect. It is concluded that sex hormones exert their effect by modifying both hypophysial secretion of ACTH and adrenocortical sensitivity to ACTH.