Pertussis toxin inhibits the angiotensin II and serotonin-induced rise of free cytoplasmic calcium in cultured smooth muscle cells from rat aorta
- 9 February 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 212 (1), 40-44
- https://doi.org/10.1016/0014-5793(87)81552-1
Abstract
Angiotensin II, serotonin and K+-depolarization cause an increase in free cytoplasmic Ca2+ in cultured smooth muscle cells. The involvement of a guanine nucleotide-binding protein has been investigated by using pertussis toxin. When smooth muscle cells were pretreated with pertussis toxin angiotensin II and serotonin-induced rise of cytosolic Ca2+ was found to be significantly reduced whereas the Ca2+ influx mediated by K+-depolarization remained unchanged. These results suggest the participation of a guanine nucleotide-binding protein in the receptor-mediated rise of intracellular Ca2+.Keywords
This publication has 22 references indexed in Scilit:
- Pertussis toxin blocks angiotensin II‐induced calcium influx but not inositol trisphosphate production in adrenal glomerulosa cellFEBS Letters, 1986
- Serotonin increases the production of inositol phosphates and mobilises calcium via the 5-HT2 receptor in A7r5 smooth muscle cellsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1986
- Leukotriene B4stimulation of phosphatidylinositol turnover in macrophages and inhibition by pertussis toxinFEBS Letters, 1986
- Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N ProteinScience, 1986
- A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid glandBiochemical and Biophysical Research Communications, 1986
- Inositol-1,4,5-trisphosphate releases calcium from skinned cultured smooth muscle cellsBiochemical and Biophysical Research Communications, 1985
- Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: Possible role of the “G proteins” in calcium mobilizationBiochemical and Biophysical Research Communications, 1984
- G proteins and dual control of adenylate cyclaseCell, 1984
- Contribution of cellular and extracellular Ca2+ during 5-hydroxytryptamine-induced contractions of rabbit ear arteryEuropean Journal of Pharmacology, 1983
- Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.The Journal of cell biology, 1982