INTRATHECAL PENICILLIN
- 3 May 1947
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 134 (1), 16-18
- https://doi.org/10.1001/jama.1947.02880180018004
Abstract
Penicillin has an irritative action on nerve tissue and may produce convulsions when applied in sufficient concentration to the cerebral cortex. Intrathecal penicillin has been used in single doses ranging from 5,000 to 100,000 units for the treatment of various inflammatory diseases of the meninges. As well as can be determined from a review of the literature, no larger single dose than 100,000 units has been used intrathecally, and no convulsions have been produced with such doses. The purpose of this article is to report a case of meningococcic meningitis in which the patient received (by error) a single massive dose of penicillin intrathecally and recovered after a series of generalized convulsions. REPORT OF A CASE History and Examination.— A white woman aged 27, married, four months pregnant, was admitted to Flushing Hospital in a comatose state. The past history was noncontributory except that she had had a slight "headKeywords
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