Comparative Study of Metabolic Effects of Estradiol Benzoate and Testosterone Propionate in Man123

Abstract

Five mg. of testosterone propionate intramusc. in 2 eunuchoids produced characteristic reduction in urinary N. inorganic P, sulfate and Na excretion. In one, urinary K was reduced. Creatinuria, when sustained at high levels by creatine ingestion, was reduced by the androgen. Basal heat production was unaltered. The eunuch-oid organism is thus quite sensitive to the metabolic effects of androgens. Five mg. of estradiol benzoate, intramusc. daily in 2 eunuchoids, one hypogonad [female] and one normal [female] induced reduction in urinary N. inorganic P and Na excretion. Urinary sulfate was probably reduced in one eunuchoid and in the women. Urinary K was elevated in the normal [female]. Otherwise it was unaffected. Creatine excretion in the eunuchoid, when sustained at high levels by creatine ingestion, was not reduced by estradiol benzoate. This is in contrast to the effect of the androgen. Basal heat production was unaltered. Several of the metabolic effects of testosterone propionate are shared by estradiol benzoate given in sufficient amts. A masculinized [female] (adreno-genital syndrome) showed none of the usual metabolic effects of estradiol benzoate. Creatinuria was increased. Hypogonad [female][female] of short stature and with high urinary gonadotrophin titers respond well to the metabolic influences of either estradiol benzoate or testosterone propionate. It is not yet clear that the ovarian secretion in physiologic amts. exerts any general anabolic influence on non-genital tissue.