Use of Compatible Platelet Transfusions in Treatment of Congenital Isoimmune Thrombocytopenic Purpura

Abstract

A newborn infant with isoimmune thrombocytopenic purpura due to incompatibility of the P1^A1 platelet antigen system was treated with transfusion of incompatible platelets and by exchange transfusion, without improvement in the thrombocytopenic purpura. After the transfusion of compatible maternal P1^A1-negative platelets, there was a sustained improvement in the platelet count and cessation of hemorrhage. Exchange transfusion combined with infusion of washed maternal platelets may be the treatment of choice in this uncommon disorder.