Über die Hydrierung ungesättigter Stoffe im Tierkörper (Biochemische Hydrierungen VII)

Abstract

The compounds were administered to rabbits by injection into the thigh muscles or by stomach tube in soln. or emulsion, in amts. not exceeding tolerance doses and daily urine collections were made. After inj. of geraniol, benzoic acid, Hildebrandt acid and dihydro Hildebrandt acid were excreted. Adm. of citronellol was followed by the excretion of dicarboxylic acid, monohydroxycarboxylic acid and benzoic acid. Following phytol, benzoic and probably phytenic acids were excreted. Benzoic acid was also recovered after the adm. of farnesol and [DELTA]-4,6-dihydro-o-tolyl alcohol. Cyclohexenol and its acetate were toxic. Feeding of cin-namic alc. was followed by excretion of benzoic and cin-namic acids; benzoic acid was formed after feeding cin-namic acid. [alpha]-Ethylcinnamaldehyde was converted into the corresponding acid and a-ethylcinnamic alc. into the acid together with benzoic acid. Benzalacetone was converted in part into [beta]-phenylethylmethylcarbinol, and benzal-methylethylketone into [beta]-phenylethyl-ethylcarbinol and propably p-hydroxyphenethyl-ethylketone. Ethylidene ace-tophenone and carvone were very toxic. Adm. of cinnamal-acetone was followed by the excretion of 6-phenyl-5-hexen-. 2-ol, dihydroxyphenylhexene, p-hydroxybenzaldehyde, 6-(p-hydroxyphenyl)-5-hexen-2-ol, and 6-(p-hydroxyphenyl)-5-hexen-2-one.