Effect of Fluoroacetate Upon Poliomyelitis in Monkeys.

Abstract

Cynomolgus monkeys were treated with 5 mg./kg. of Na monofluoroacetate on the day of, or 3 days following, subcut. inoculation of Type 1 poliomyelitis virus. Of 42 monkeys which received drug on the day of virus, 9 resisted clinical infection as did 5 of 23 animals receiving drug on the 3d day after virus. All control animals became paralyzed. Citrate did not accumulate in brain tissue of drug-treated monkeys, suggesting that the action of fluoroacetate was at some site other than the brain. The significance of these findings is discussed.