Effect of Secretin on Colonic DNA Synthesis
- 1 September 1978
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 158 (4), 521-523
- https://doi.org/10.3181/00379727-158-40238
Abstract
This study examined whether or not secretin inhibited pentagastrin stimulated growth of colonic mucosa in rats. Pentagastrin (250 .mu.g/kg) caused an approximate doubling of mucosal DNA synthesis which was completely prevented by secretin in doses of 37.5 and 75 U[unit]/kg. The effect of secretin was dose dependent and occurred with as little as 9 U/kg. Secretin had no effect on either DNA synthesis or content when administered by itself. The dose of 75 U secretin/kg also completely prevented a 60% increase in DNA content stimulated by pentagastrin.This publication has 3 references indexed in Scilit:
- Proximal enterectomy stimulates distal hyperplasia more than bypass or pancreaticobiliary diversionGastroenterology, 1978
- Specific stimulation of gastric acid secretion by a pentapeptide derivative of gastrinJournal of Pharmacy and Pharmacology, 1966
- A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acidBiochemical Journal, 1956