Chemical and biological aspects of a new family of phosphorus‐containing antibiotics

Abstract

The chemical, physical, and biological properties of a group of phosphorus‐containing antibiotics are reviewed. Included in this family of antibiotics are the following compounds or mixtures of compounds: diumycin, macarbomycin, moenomycin, prasinomycin, 803GRP, 11,837RP, and 19,402RP. Among the aspects discussed are: antimicrobial activity in vitro, long duration of activity, toxicity, use in animal nutrition, cross resistance, mode of action, chemical and physical properties, and degradation studies.