Characterization of a novel structural member, LukE‐LukD, of the bi‐component staphylococcal leucotoxins family
- 2 October 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 436 (2), 202-208
- https://doi.org/10.1016/s0014-5793(98)01130-2
Abstract
A new member of the staphylococcal bi-component leucotoxins family, LukE (32 kDa) and LukD (34.3 kDa) has been characterized from Staphylococcus aureus strain Newman. LukE was 58–68% identical with the class S proteins, whereas LukD was 71–77% identical with the class F proteins of the family. A partial immunoreactivity with the various affinity-purified antibodies specific for the other proteins was observed. Immunoprecipitation assay and gene probing confirmed a 30% frequency among human clinical isolates, differing from the distribution of the other known leucotoxins (PStaphylococcus aureus.Keywords
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