CONVULSIONS IN CEREBELLUM AND CEREBRUM INDUCED BY ß-CHLORINATED AMINES
- 31 December 1949
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 160 (1), 195-202
- https://doi.org/10.1152/ajplegacy.1949.160.1.195
Abstract
The convulsant activity of a series of 25 beta-chloroethylamines was studied in cats and the necessary configuration for convulsant activity found to be CH3N(C2H4C1)2 or CH3N(C2H5)C2H3Cl2. The threshold dose of the compounds is approx. halved and the time of onset of seizures greatly reduced by inhalation of gas mixtures containing 15-30% CO2- Seizure discharge was first observed in the leads over the cerebellum.Keywords
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