Met-enkephalin-Arg6-Phe7, present in high amounts in brain of rat, cattle and man, is an opioid agonist
- 1 November 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 288 (5786), 88-90
- https://doi.org/10.1038/288088a0
Abstract
The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers. Recently isolated from bovine adrenals was another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7. This new heptapeptide is bound in human, rat and bovine striatum in concentrations comparable with or greater than that of Leu-enkephalin. This molecule should not be considered as a mere precursor of Met-enkephalin. A pharmacological study indicates that this naturally occurring enkephalin has similar properties to the 2 enkephalins characterized earlier.This publication has 12 references indexed in Scilit:
- EFFECTS OF CHANGES IN THE STRUCTURE OF ENKEPHALINS AND OF NARCOTIC ANALGESIC DRUGS ON THEIR INTERACTIONS WITH μ‐ AND δ‐RECEPTORSBritish Journal of Pharmacology, 1980
- Isolation and structure of pro-methionine-enkephalin: Potential enkephalin precursor from porcine hypothalamusProceedings of the National Academy of Sciences, 1979
- Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum.Proceedings of the National Academy of Sciences, 1979
- Substance P inhibits nicotinic activation of chromaffin cellsNature, 1979
- Binding assay for opioid peptides with neuroblastoma × glioma hybrid cells: Specificity of the receptor siteBrain Research, 1978
- Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.Proceedings of the National Academy of Sciences, 1977
- Radioimmunoassay of brain peptides: Evaluation of a methodology for the assay of β-endorphin and enkephalinLife Sciences, 1977
- Endogenous opioid peptides: multiple agonists and receptorsNature, 1977
- Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.Proceedings of the National Academy of Sciences, 1976
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975