Eicosanoid Synthesis by Human Urinary Bladder Mucosa: Pathological Implications
- 1 January 1987
- journal article
- research article
- Published by Wiley in British Journal of Urology
- Vol. 59 (1), 36-39
- https://doi.org/10.1111/j.1464-410x.1987.tb04575.x
Abstract
Summary— Biopsies of human urinary bladder mucosa obtained during cystoscopy were shown to release eicosanoids in the following order: prostacyclin (PGI2), prostaglandin E2 (PGE2), prostaglandin F2x (PGF2x) and thromboxane A2 (TXA2). The total and the relative amounts of eicosanoids released were similar to those reported for the rat urinary bladder. These eicosanoids may play a role in modulating the tone and contractility of the bladder as well as affecting cytoprotection of the mucosa. In view of the abundant release of eicosanoids by the bladder, caution must be exercised when considering urinary eicosanoid excretion as reflecting production by the systemic vasculature and/or the kidneys.This publication has 21 references indexed in Scilit:
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