Fortimicin a production by Micromonospora olivoasterospora in a chemically defined medium.
- 1 January 1977
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 30 (12), 1064-1072
- https://doi.org/10.7164/antibiotics.30.1064
Abstract
A chemically defined medium was devised in order to study the requirements for fortimicin A production by M. olivoasterospora KY 11515. Soluble starch was the best C source; NH4Cl and NH4NO3 were suitable N sources for the growth and fortimicin production. Amino acids such as L-arginine, L-asparagine, L-aspartic acid and L-glutamic acid showed some stimulatory effects on growth and antibiotic production of M. olivoasterospora, while L-serine stimulated only antibiotic production and L-citrulline only the growth. K2HPO4, MgSO4 .cntdot. 7H-2O and CaCO3 were essential especially for the antibiotic production. The most important finding was that vitamin B12, Co and Ni showed marked stimulatory effects on fortimicin A production.This publication has 2 references indexed in Scilit:
- Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation a biological properties of fortimicins.The Journal of Antibiotics, 1977
- A chemically defined fermentation medium for the growth ofMicromonospora purpureaBiotechnology & Bioengineering, 1966