Putative Reverse Transcriptase Intermediates of Human Hepatitis B Virus in Primary Liver Carcinomas
- 7 February 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 231 (4738), 594-596
- https://doi.org/10.1126/science.2418501
Abstract
Nucleocapsid-pol fusion proteins have been detected by serological screening hepatocellular carcinoma tissues that contain hepatitis B virus (HBV) DNA. The existence of these fusion proteins suggests that HBV may synthesize its reverse transcriptase in a fashion analogous to the way that retroviruses synthesize and process a precursor. The accumulation of HBV reverse transcriptase intermediates in tumorous tissues and not in other tissues may be related to the absence of viral core particles and possibly contributes to tumor development.This publication has 16 references indexed in Scilit:
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