THE SOLUBILIZATION OF MICROSOMAL ANTIBODY ACTIVITY BY THE SPECIFIC INTERACTION BETWEEN THE CRYSTALLIZABLE FRACTION OF γ-GLOBULIN AND LYMPH-NODE MICROSOMES

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Abstract
When lymph-node microsomes are treated under a variety of conditions, their antibody activity is diminished and antibodies may be identified in the soluble phase. The conditions which are effective in separating antibodies from microsomes indicate that the linkages involved are not convalent. It is inferred that the microsome-antibody complex is re-versible and due to a specific interaction between microsomal components and that segment of antibody (or gamma-globulin) which corresponds to the crystallizable fraction obtained by papain digestion of rabbit gamma-globulin.