Synthesis of estradiol-pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells
- 9 October 2006
- journal article
- research article
- Published by Springer Nature
- Vol. 5 (11), 996-999
- https://doi.org/10.1039/b606117f
Abstract
The synthesis, physico-chemical properties, cellular localization and photocytotoxicity of estradiol–pheophorbide a conjugates in estrogen-dependent cancer and vascular endothelial cells are described with the aim of increasing the photodynamic activity by targeting the nucleus of both tumor and blood vessel cells.Keywords
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