beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.
- 1 March 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (5), 1389-1390
- https://doi.org/10.1073/pnas.81.5.1389
Abstract
.beta.h-Endorphin-(1-27), a naturally occurring fragment of human .beta.-endorphin (.beta.h-endorphin), diminishes the analgesic effect of .beta.h-endorphin when coinjected intracerebroventricularly into mice. A parallel shift in the dose-response curve of .beta.h-endorphin in the presence of .beta.h-endorphin-(1-27) suggests competition at the same site. The potency of .beta.h-endorphin-(1-27) in antagonizing analgesia is > 4 times greater than that of the opiate antagonist naloxone.This publication has 17 references indexed in Scilit:
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