Preparation of the 3-monosulphates of cholic acid, chenodeoxycholic acid and deoxycholic acid
- 1 May 1976
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 155 (2), 401-404
- https://doi.org/10.1042/bj1550401
Abstract
The 3-sulfates of cholic, chenodeoxycholic and deoxycholic acids were prepared as crystalline disodium salts. It is possible to prepare specific sulfate esters of polyhydroxy bile acids and to remove protecting acyl groups without removing the sulfate. A study of bile acid sulfate solvolysis showed that none of the usual methods give the original bile acid in major yield in a single step. An understanding of the preparation, properties and methods of solvolysis of bile acid sulfates is basic for investigations of cholestasis and liver disease [in humans].This publication has 11 references indexed in Scilit:
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