A Point Mutation in the c- myc Locus of a Burkitt Lymphoma Abolishes Binding of a Nuclear Protein
- 24 June 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 240 (4860), 1776-1780
- https://doi.org/10.1126/science.2454510
Abstract
A 20-base pair region in the first intron of the human c-myc gene was identified as the binding site of a nuclear protein. This binding site is mutated in five out of seven Burkitt lymphomas sequenced to date. To investigate the protein-recognition region in greater detail, the abnormal c-myc allele from a Burkitt lymphoma line (PA682) that carries a t(8;22) chromosomal translocation was used. A point mutation in the binding region of the PA682 c-myc DNA abolished binding of this nuclear protein. This protein may be an important factor for control of c-myc expression, and mutations in its recognition sequence may be associated with c-myc activation in many cases of Burkitt lymphoma.This publication has 37 references indexed in Scilit:
- Mutations in the First Exon Are Associated with Altered Transcription of c- myc in Burkitt LymphomaScience, 1987
- Enhancement of mRNA nuclear transport by promoter elementsCell, 1987
- A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cellsNature, 1986
- Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphomaNature, 1984
- Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cellsCell, 1984
- Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locusNature, 1984
- Synthesis of Kappa Light Chains by Cell Lines Containing an 8;22 Chromosomal Translocation Derived from a Male Homosexual with Burkitt's LymphomaScience, 1983
- Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin μ locus in a Burkitt lymphomaNature, 1983
- Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphomaNature, 1983
- The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphomaCell, 1983