Actinomycin D Effects in Frog Embryos: Evidence for Sequential Synthesis of DNA-Dependent RNA
- 13 September 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 141 (3585), 1063-1064
- https://doi.org/10.1126/science.141.3585.1063
Abstract
Early gastrulae of Rana pipiens exposed to actinomycin D for 2 days were then cultured in saline. The resulting larvae were immotile; histological examination revealed impaired development of axial nerve and muscle tissues, but normal differentiation of sensory, pronephric, heart, and digestive tissues; this suggests sequential synthesis of the different tissue-specific molecules of DNA-dependent RNA.Keywords
This publication has 8 references indexed in Scilit:
- The synthesis of ribonucleic acid in sea urchin embryosBiochemical and Biophysical Research Communications, 1963
- Polypeptide Synthesis in Sea Urchin Embryogenesis: An Examination with Synthetic PolyribonucleotidesScience, 1963
- Effet de l'actinomycine sur la différenciation nerveuse de l'ectoblaste chez les embryons d'amphibienExperimental Cell Research, 1963
- Effects of Actinomycin D on MorphogenesisNature, 1963
- Structure-Activity Correlations of Actinomycins and their DerivativesNature, 1962
- Stimulation of phenylalanine incorporation by polyuridylic acid in homogenates of sea urchin eggsBiochemical and Biophysical Research Communications, 1962
- Interrelation of messenger polyribonucleotides and ribosomes in the sea urchin egg during embryonic developmentBiochemical and Biophysical Research Communications, 1962
- The effect of ethionine on the development of muscular response in the frog embryoJournal of Experimental Zoology, 1961