RENAL EXCRETION OF SULFATE

Abstract

Injected sulfate is excreted according to a different law than endogenous sulfate in dogs. At high concs. of sulfate in serum, sulfate excretion is in part a function of serum conc. and at times is nearly proportional to the increase in conc. Sulfate clearance varies systematically with serum conc. increasing as the serum conc. rises. Sulfate excretion is in the main independent of the associated cation. Sulfate excretion is somewhat increased by the simultaneous inj. of NaCl. Chloride excretion is almost completely repressed by sulfate excretion, even when a large NaCl infusion is given simultaneously with the sulfate infusion. The extent to which ions may be excreted according to their own characteristic laws and the means by which electroneutrality of urine is maintained are discussed.