THE REPONSE OF HYPOPHYSECTOMIZED MALE KILLIFISH TO PROLONGED TREATMENT WITH SMALL DOSES OF THYROTROPIN1
- 1 November 1954
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 55 (5), 589-592
- https://doi.org/10.1210/endo-55-5-589
Abstract
Hypophysectomized male killiflsh (Fundulus heteroclltus) were injected thrice weekly at 20[degree]C for one month with Armour''s thyrotropin No. 2R3 at dosage levels of 1 [mu]g, 0.1 [mu]g and 0.01 [mu]g/g weight/injection. The highest dosage level caused thyroid stimulation and maintained a low degree of exophthalmos. The medium dosage level was barely sufficient to maintain the thyroids at a normal level and induced a very slight degree of exophthalmos. At both these dosage levels the treatment relieved the anemia due to hypophysectomy. The treatments had no effect on the liver size or incidence of renal lithiasis but, at the highest dosage level, there was a slight stimulation of the testes.Keywords
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