Lysergic Acid Diethylamide: Effect on Histone Acetylation in Rabbit Brain
- 13 June 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 188 (4193), 1122-1123
- https://doi.org/10.1126/science.1215990
Abstract
Lysergic acid diethylamide increased acetylation of histones in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration of the drug at doses of 10 and 100 micrograms per kilogram of body weight. Evidence for the stimulation of acetylation in individual histone bands was obtained after separation by electrophoresis on polyacrylamied gels.Keywords
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