DOES PIRENZEPINE DISTINGUISH BETWEEN ‘SUBTYPES’ OF MUSCARINIC RECEPTORS?
Open Access
- 1 December 1982
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 77 (4), 567-569
- https://doi.org/10.1111/j.1476-5381.1982.tb09332.x
Abstract
Pharmacological studies with pirenzepine were carried out on the isolated ileum and atrium of the guinea-pig and on the acid secretion from the isolated stomach of the mouse. Pirenzepine inhibited the bethanechol-evoked changes in all three organs in a dose-dependent manner. The slopes of the Schild-plots confirmed the competitive nature of the antagonism by pirenzepine. The estimated pA2-values were very similar. Based on these data, it might be concluded that pirenzepine is an anticholinoceptor compound without specific affinity for gastric muscarinic receptors.Keywords
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