Solubilization of dl-.ALPHA.-tocopherol by bile salts, polysorbate 80 and egg lecithin.

Abstract

The solubilization dl-α-tocopherol (VE) into micellar solutions of bile components and non-ionic polysorbate 80 (PS-80) was studied. Dihydroxy conjugated bile salt showed a higher saturation ratio than trihydroxy conjugated bile salt. The mixed micelles of bile salt with egg lecithin (PC) solubilized more VE than the bile salt alone. PS-80 micelles showed a saturation ratio approximately 20 times higher than those of bile salts. When PC was included in PS-80micellar solution, the solubility of VE decreased with increasing PC content. The order of micellar size of bile salts and PS-80 solubilizing VE, as measured by gel filtration, was sodium taurocholate, sodium taurodeoxycholate and PS-80.