Effect of Liver Ischemia on Plasma in the Dog, as Measured by Electrophoretic Analysis.

Abstract

Summary Successive surgical interference with the blood supply to the liver is followed by a decrease in the total proteins. The greater the interference with the circulation, the lower is the albumin level. The higher globulin level is due to an increase in the β + Φ + γ fractions. It is suggested that a longer lapse of time after the experimental reduction of the blood supply permits the establishment of an adequate collateral circulation and tends to reestablish the normal production of proteins by the liver. In acutely induced fatal hepatic coma no large changes in the electrophoretic patterns of the dog plasmas were observed during the short survival time.