Synthesis and assembly of hepatitis B virus surface antigen particles in yeast
- 1 July 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 298 (5872), 347-350
- https://doi.org/10.1038/298347a0
Abstract
The surface antigen of hepatitis B virus was synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5''-flanking region of yeast alcohol dehydrogenase I as a promoter to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.This publication has 32 references indexed in Scilit:
- Hepatitis B virus and hepatocellular carcinoma: Molecular biology provides further evidence for an etiologic associationHepatology, 1981
- Hepatitis B virus genes and their expression in E. coliNature, 1979
- Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coliNature, 1979
- Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigenNature, 1979
- Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322Nature, 1979
- Cloning and endonuclease mapping of the hepatitis B viral genomeNature, 1979
- Role of hepatitis b virus in primary liver cancerJournal of Toxicology and Environmental Health, 1979
- Cellular and Humoral Immunity in Guinea Pigs to Two Major Polypeptides Derived from Hepatitis B Surface AntigenJournal of General Virology, 1978
- The proteins of hepatitis B dane particle coresJournal of Medical Virology, 1977
- Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from Dane particles.Proceedings of the National Academy of Sciences, 1975