Nerve allografts and histocompatibility in dogs
- 1 November 1977
- journal article
- research article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 47 (5), 737-743
- https://doi.org/10.3171/jns.1977.47.5.0737
Abstract
✓ The histocompatibility requirements for successful frozen nerve allografts were studied in 46 dogs. Major canine histocompatibility (DLA) differences appeared to be of vital importance for nerve regeneration and function, as judged by histological and electromyographic performance 7 to 9 months after grafting. Minor histocompatibility differences did not appear to lead to rejection of the frozen nerve allografts. Graft irradiation did not improve the acceptability of frozen DLA-mismatched grafts. The effect of DLA matching was much more pronounced in allografts 7 cm long than in allografts 4 cm long. The results indicate the need for a bank of frozen human histocompatible (HLA) nerve allografts, and a study of the effect of partial or complete HLA matching on their survival.Keywords
This publication has 15 references indexed in Scilit:
- Experience with allografts in the surgery of peripheral nerves (experimental study)Acta Neurochirurgica, 1976
- Experience with homologous lyophilised nerve grafts in the treatment of peripheral nerve injuriesActa Neurochirurgica, 1975
- Reappraisal of homologus nerve craftsClinical Neurology and Neurosurgery, 1974
- A comparison of the effects of irradiation and immunosuppressive agents on regeneration through peripheral nerve allografts: An ultrastructural studyActa Neuropathologica, 1973
- THE PRODUCTION AND EVALUATION OF DOG ALLOLYMPHOCYTOTOXINS FOR DONOR SELECTION IN TRANSPLANTATION EXPERIMENTSTransplantation, 1971
- Peripheral Nerve Grafts: Experimental Studies in the Dog and Chimpanzee to Define Homograft LimitationsJournal of Neurosurgery, 1970
- APPLICATION OF TISSUE TRANSPLANT TECHNIQUE TO EXPERIMENTAL NERVE GRAFTINGPublished by Wolters Kluwer Health ,1969
- The Failure of Whole Fresh Homogenous Nerve Grafts in ManJournal of Neurosurgery, 1945
- Recovery of fibre numbers and diameters in the regeneration of peripheral nervesThe Journal of Physiology, 1943
- NERVE GRAFTING AS A MEANS OF RESTORING FUNCTION IN LIMBS PARALYSED BY GUNSHOT OR OTHER INJURIESBMJ, 1917