THE DEVELOPMENT OF BONE

Abstract

In the studies here recounted, three different aspects of the problems involved in the development of bone are discussed, as indicated in the title. All three studies are closely interwoven and cannot be considered separately without much needless repetition and reduplication. Consideration is given each aspect in its proper relation to various portions of the work to be described, and they must be considered collectively for a proper elucidation of the problems discussed and for an interpretation of the results of the work which has been accomplished. The process of the transport of calcium salts in the body and their deposition in bone have already been discussed in previous papers. But a much more thorough, detailed and minute study has now been made of the process of calcification of the cartilaginous and bony matrix of the skeleton, and the results obtained are embodied in this paper. It is to be