Mammary Cancer in Castrate Male Mice Receiving Ovarian and Hypophyseal Grafts at Various Ages.

Abstract

Syngenesio-transplants of ovaries made at one month of age caused mammary cancer in 5% of castrate male mice of strain A. The tumor incidence rose to 32.5%, if anterior hypophyses were grafted together with ovaries. Transplantation of anterior hypophyses alone failed to produce breast cancer. No mammary tumors occurred in castrates into which ovaries, anterior hypophyses alone or anterior hypophyses in combination with ovaries were grafted at 7 months of age. Thus in male mice, an age factor which is independent of the testicle operates in the production of breast cancer by ovarian and anterior hypophyseal grafts.